1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
Apoptosis Activator 2
CAS: 79183-19-0
Molecular Formula: C15H9Cl2NO2
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE - Names and Identifiers
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE - Physico-chemical Properties
| Molecular Formula | C15H9Cl2NO2 |
| Molar Mass | 306.14 |
| Density | 1.494 |
| Boling Point | 470.6±55.0 °C(Predicted) |
| Flash Point | 238.4℃ |
| Appearance | Orange to red solid. |
| pKa | -2.69±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Sensitive | Light Sensitive |
| Use | An indoledione caspase activator |
| In vitro study | Aptopia Activator 2 (20 μm) was at a reduced cyto c concentration, increasing the Apaf-1 fraction in apoptotic bodies 1.5-fold to 33%. Apoptosis Activator 2 (20 μm) was at a reduced level of cyto c, increasing the degree of activation of caspase-3 4-fold. Apoptosis Activator 2 strongly induced caspase-3 activation, PARP cleavage, and DNA division, and eventually killed cells with an IC50 of 4 μm. Apoptosis Activator 2 induces Apoptosis in PBL, HUVEC, Jurkat, Molt-4, CCRF-CEM, BT-549, MDA-MB-468 and NCI-H23, with IC50 of 50 μm, 43 μm and 4 μm, respectively, 6 μm, 9 μm, 20 μm, 44 M and 35 M. Apoptosis Activator 2 inhibited most of the tumor cell lines tested, with 50-100% inhibition of cell growth at 10 μm. Apoptosis Activator 2 induces cell death by triggering the formation of apoptotic bodies. The expression level of En1 had no significant effect on the survival rate of the ventral midbrain in culture. Apoptosis activator 2 (10 μm) induced Apoptosis in AGS cells was evaluated by DNA ladder electrophoresis and TUNEL assay for Apoptosis. Apoptosis activator 2(10 μm) enhanced the induction of Apoptosis by anti-TROP2 antibody conjugated liposomes. Cyclohexamide (10 μg/mL) or zVAD (50 μm) acts on cultured neurons to significantly prevent the toxicity of Apoptosis Activator 2. Apoptosis activator 2(3 μm) causes many neurons to undergo nuclear condensation, suggesting that cell death involves Apoptosis. DHT(10 nM) or E2(10 nM) acts on cultured neurons to significantly prevent the toxicity of apotosis Activator 2. |
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | 3077 |
| HS Code | 29145090 |
1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE - Introduction
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP division, DNA fragmentation, leading to cell destruction (Apaf-1-dependent),IC50 is about 4 μM, inhibiting HMEC, PREC and MCF-10A cell activity.
Last Update：2022-10-16 17:41:50
![1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE](http://res.chembk.com/assets/images/structure/310794.gif)
Supplier List
Spot supply
Product Name: Apoptosis Activator 2 Visit Supplier Webpage Request for quotationCAS: 79183-19-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Apoptosis Activator 2 Visit Supplier Webpage Request for quotationCAS: 79183-19-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History